MGH Appointment: Associate Neurologist
HMS Appointment: Associate Professor of Neurology
MGH Address: CNY 114: 2001
MGH Phone Number: 617-726-1254
Patient Office Phone Number: 617-726-5532
Patient Office Location: ACC 835
E-Mail Address: hersch@helix.mgh.harvard.edu
FAX Number: 617-724-1480
Undergraduate Education: American University
Graduate and/or Medical School: Boston University, PhD, Boston University, MD
Residencies and Fellowships: Emory University: Medical internship, Neurology Residency, Neurobehavior Fellowship
Foreign Language Spoken:
Certification by an American Specialty Board: Neurology
Primary Specialty: Huntington's disease
Other Specialties: Memory and movement disorders
Research Interests: Basic mechanisms and experimental therapeutics for Huntington's Disease.
Clinical Interests: Huntington's disease.
Representative Publications:
Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson
WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ. Therapeutic
effects of cystamine in a murine model of Huntington's disease. J Neurosci
2002;22:8942-50.
Dedeoglu, A, Kubilus, JK, Yang, L, Ferrante, KL, Hersch, SM, Beal, MF,
Ferrante, RJ. Creatine therapy provides neuroprotection after onset of
clinical symptoms in Huntington¹s disease transgenic mice. J. Neurochem.
2003: 85:1359-67.
Apostol, BL, Kazantsev, A, Raffioni, S, Illes, K, Pallos, J, Bodai, L,
Slepko, N, Bear, JE, Gertler, FB, Hersch, S, Housman, DE, Marsh, JL. A
cell-based assay for aggregation inhibitors as therapeutics of
polyglutamine-repeat disease and validation in Drosophila. PNAS, 2003,
100:5950-5955
Hersch SM. Huntington¹s disease: prospects for neuroprotective therapy 10
years after the discovery of the causative genetic mutation. Curr Opinion in
Neurology, 2003: 16:501-506.
Ferrante, RJ, Kubilus, JK, Lee, J, Ryu, H, Beson, A, Zucker, B, Smith, K,
Kowall, N, Ratan, RR, Luthis-Carter, R, Hersch, SM. Histone deacetylase
inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative
phenotype in Huntington¹s disease mice. J. Neurosci 2003, 23:9418-9427
Huntington Study Group. Dosage effects of riluzole in Huntington's disease:
A multicenter placebo-controlled study. Neurology 2003; 61:1551-1556.