MGH Appointment: Assistant Geneticist
HMS Appointment: Assistant Professor Of Neurology
MGH Address: Cny 6025
MGH Phone Number: 726-8307 (Office), 726-4642 (Lab)
Patient Office Phone Number:
Patient Office Location:
E-Mail Address: wasco@helix.mgh.harvard.edu
Fax Number: 726-5677
Undergraduate Education: B.S., University Of Connecticut
Graduate And/Or Medical School: Ph.D., Albert Einstein College Of Medicine
Residencies And Fellowships: Post-Doctoral Fellowship, Mit
Foreign Language Spoken:
Certification By An American Specialty Board:
Primary Specialty: Alzheimer's Disease
Other Specialties:
Research Interests: Molecular biology and genetic studies of the process of neuronal cell death in Alzheimer's disease and normal aging. Characterization of the members of the APP-like gene family and the presenilin proteins. Studies of calsenilin, and other neuronal calcium binding proteins, in Alzheimer's disease
Clinical Interests:
Representative Publications:
Kovacs DM, Fausett HJ, Page KJ, Kim T-W, Moir RD, Merriam DE, Hoillister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE and Wasco W (1996) Alzheimer associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Medicine 2, 224-229.
Buxbaum JD, Choi E-K, Luo Y, Lilliehook C, Crowley AC, Merriam DE and Wasco W. (1998) Calsenilin: a novel calcium-binding protein which interacts with the presenilins and regulates the levels of a presenilin fragment. Nature Medicine I4, 1177-1181.