Cellular Differentiation and Growth: Differentiation is the name given to the processes by which a few embryonic cells divide and give rise to many different specialized tissues containing millions of cells acting in a coordinated manner to carry out the complex bodily functions required for normal growth and development. Alterations in the regulation of differentiation and growth is characteristic of tumors including those that arise in the brain.
Monoclonal Antibodies: These antibodies have the capability to bind to predetermined molecules and thereby identify structures that may be absolutely unique for specific cell types, including those that make up brain tumors. They can also be combined with toxins, chemotherapy agents, or radioactive compounds to therpaeutically target these to tumor cells after patient administration.
Immunologic Studies: The body's immune system is made up of numerous substances and different types of specialized cells that allow for protection against anything that can be recognized as foreign, including brain tumors. Biologic response modifiers, such as interleukins and interferons, and immune reaction cells, such as LAK (lymphocyte activated killer) cells and TIL (tumor infiltrating lymphocytes) and activated macrophages, are being examined in this regard.
Physiology of Brain: The "Blood-Brain Barrier" (tight junctions of brain capilaries) is studied to understand how this protective mechanism of the brain can be manipulated to improve delivery of therapeutic chemicals.
Other Areas of Brain Tumor Research: Projects which may relate concepts of neurobiology or oncology to help understand and treat primary brain tumors better are also considered for funding by the Preuss Foundation.